Combinib contains Dasatinib, which is a targeted cancer medicine.
It is mainly used to treat certain blood cancers like chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).

Mechanism 

• Some blood cancers grow because of an abnormal protein called BCR-ABL tyrosine kinase.

• Dasatinib (Combinib) blocks this protein.

• This stops the signals that make cancer cells grow and multiply.

• It also blocks some other kinases involved in cancer cell survival.

  Uses

  • Chronic myeloid leukemia (CML) in adults and children

  • Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL)

  • Used when patients cannot tolerate other medicines like Imatinib, or when the cancer does not respond to them

    Adverse Effects 

    Common side effects:

    • Headache

    • Nausea, vomiting, diarrhea

    • Skin rash

    • Muscle or joint pain

    • Tiredness