Folitrax contains Methotrexate, which is a disease-modifying anti-rheumatic drug (DMARD) and also a chemotherapy agent.
It is used in low doses for autoimmune diseases (like arthritis) and in higher doses for some cancers.
Mechanism
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Methotrexate blocks an enzyme called dihydrofolate reductase (DHFR).
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This stops the making of DNA, RNA, and proteins that cells need to grow.
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In cancer, it slows down rapidly dividing tumor cells.
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In autoimmune diseases, it reduces overactive immune system activity.
Uses
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Autoimmune diseases
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Rheumatoid arthritis
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Psoriasis
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Ankylosing spondylitis
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Cancers
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Leukemia
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Lymphoma
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Breast cancer
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Head and neck cancers
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Ectopic pregnancy (to stop abnormal pregnancy growth)
Adverse Effects
Common side effects:
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Nausea, vomiting, diarrhea
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Mouth ulcers
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Loss of appetite
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Tiredness
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Mild hair loss
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