Nitnib contains Nintedanib, a tyrosine kinase inhibitor.

It comes in capsule form and is taken orally.

Used mainly for certain lung diseases and in some types of cancer.

Mechanism

• Nintedanib blocks tyrosine kinases—enzymes involved in cell signaling.

• Specifically, it inhibits VEGFR, PDGFR, and FGFR.

• By blocking these, it slows fibroblast activity and blood vessel formation, reducing lung scarring and tumor growth.

  Uses

  • Idiopathic Pulmonary Fibrosis (IPF) – slows lung scarring.

  • Chronic Fibrosing Interstitial Lung Diseases (progressive) – slows disease progression.

  • Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) – reduces lung fibrosis.

  • Non-Small Cell Lung Cancer (NSCLC) – used in combination with chemotherapy for advanced disease.

    Adverse Effects 

    Common side effects:

    • Diarrhea

    • Nausea, vomiting

    • Abdominal pain

    • Loss of appetite

    • Headache

    • Weight loss