CICBASE contains Prucalopride, a medicine used to treat chronic constipation in adults, especially when conventional laxatives do not provide sufficient relief. It is a prokinetic agent that helps the intestines move stool more effectively and regularly.

Mechanism of action:
Prucalopride is a selective serotonin 5-HT4 receptor agonist. It stimulates these receptors in the gastrointestinal tract, which enhances colonic peristalsis (wave-like movements of the bowel). This helps move stool through the intestines, making bowel movements easier and more frequent.

Uses:

• Chronic idiopathic constipation in adults

• Particularly used when dietary measures and standard laxatives fail

• Helps improve bowel movement frequency, consistency, and reduces bloating or discomfort

Adverse effects:
Common side effects include headache, nausea, diarrhea, abdominal pain, and bloating. Some patients may experience dizziness, fatigue, or palpitations. Rare side effects can include severe allergic reactions or changes in heart rhythm in patients with pre-existing heart conditions.