Vonavir is a fixed-dose combination antiretroviral medicine containing Tenofovir disoproxil fumarate (TDF) + Lamivudine (3TC) + Efavirenz (EFV). It is widely used as a single-tablet regimen for managing HIV infection.

Mechanism of Action

• Tenofovir & Lamivudine → Both are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). They block the HIV reverse transcriptase enzyme, preventing the virus from making new DNA.

• Efavirenz → A non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds directly to reverse transcriptase, further stopping viral replication.

• Together, they reduce HIV multiplication, lower viral load, and improve immune function (CD4 cell count).

  Uses 

  • Treatment of HIV-1 infection in adults and adolescents.

  • Helps reduce complications of HIV and improves quality of life.

  • Also lowers the risk of HIV transmission when viral load is suppressed.

    Adverse Effects

    Common side effects:

    • Dizziness, insomnia, abnormal dreams (due to efavirenz)

    • Headache, tiredness

    • Nausea, vomiting, diarrhea

    • Skin rash