Trilavir E is a combination antiviral medication used primarily in the management of HIV (Human Immunodeficiency Virus) infection. It helps reduce the viral load in the body, supports immune function, and lowers the risk of HIV-related complications. The exact formulation may vary by manufacturer, but it typically contains a mix of antiretroviral agents such as Tenofovir Disoproxil Fumarate, Lamivudine, and Efavirenz.

Mechanism of Action

Each component works synergistically to suppress HIV replication:

1. Tenofovir Disoproxil Fumarate (TDF) – a nucleotide reverse transcriptase inhibitor (NtRTI) that blocks the action of reverse transcriptase, an enzyme the virus needs to replicate.

2. Lamivudine (3TC) – a nucleoside reverse transcriptase inhibitor (NRTI) that also prevents viral DNA synthesis by inhibiting reverse transcriptase.

3. Efavirenz (EFV) – a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds directly to reverse transcriptase, altering its structure and stopping viral replication.

   Uses

   • Treatment of HIV-1 infection in adults and adolescents.

   • Part of combination antiretroviral therapy (cART) for long-term viral suppression.

   • Helps prevent HIV-related illnesses and transmission when taken consistently.

     Adverse Effects

     • Dizziness, headache, or fatigue

     • Nausea, vomiting, or diarrhea

     • Trouble sleeping or vivid dreams (mainly due to Efavirenz)

     • Rash or mild skin irritation