Refinlar contains Dabrafenib, which is a targeted cancer medicine. It belongs to a group of drugs called BRAF inhibitors. It is used to treat cancers that have a specific gene change called BRAF V600 mutation.

Mechanism
Some cancers grow because of changes (mutations) in the BRAF gene, which makes cancer cells grow uncontrollably. Dabrafenib blocks the abnormal BRAF protein, which slows down or stops the growth of cancer cells.

Uses

• Melanoma (skin cancer) with BRAF V600 mutation

• Non-small cell lung cancer (NSCLC) with BRAF V600 mutation

• Thyroid cancer with BRAF V600 mutation

• Often used alone or in combination with another medicine (like trametinib) for better effect

  Adverse Effects
  Common side effects:

  • Fever

  • Tiredness

  • Nausea, vomiting, diarrhea

  • Loss of appetite

  • Joint pain, muscle pain

  • Skin rash, thickening of skin, warts