Axentri contains maraviroc, an antiviral medicine used in the treatment of HIV infection. It is a type of drug called a CCR5 antagonist that helps prevent HIV from entering human immune cells.

Mechanism of Action

• HIV enters immune cells (CD4+ T-cells) using certain co-receptors, mainly CCR5 or CXCR4.

• Maraviroc specifically blocks the CCR5 receptor on the surface of immune cells.

• By doing so, it prevents CCR5-tropic HIV-1 from attaching and entering the cells.

• This reduces viral replication and helps preserve immune function.

  Uses 

  • Used in combination with other antiretroviral drugs for the treatment of HIV-1 infection.

  • Effective only against CCR5-tropic HIV-1 (not against CXCR4-tropic or dual/mixed HIV strains).

    Adverse Effects

    Common side effects:

    • Cough, fever, upper respiratory tract infections

    • Rash, dizziness

    • Stomach pain, nausea, diarrhea

    • Muscle or joint pain