Biobin 100mg Injection contains Cytarabine, a chemotherapy medication used to treat certain types of blood cancers, including:

• Acute Myeloid Leukemia (AML)

• Chronic Myelogenous Leukemia (CML)

• Meningeal Leukemia (cancer affecting the membranes of the brain and spinal cord)

Cytarabine is an antimetabolite that interferes with the growth of cancer cells by disrupting DNA and RNA synthesis.

Mechanism of Action

Cytarabine is a nucleoside analog that inhibits DNA polymerase, an enzyme essential for DNA replication. By incorporating into the DNA strand during replication, it causes chain termination, leading to cell death. This mechanism is particularly effective against rapidly dividing cancer cells.

Uses

Biobin 100mg Injection is primarily used for:

• Acute Myeloid Leukemia (AML)

• Chronic Myelogenous Leukemia (CML)

• Meningeal Leukemia

It may be used alone or in combination with other chemotherapy agents as part of a treatment regimen.

Adverse Effects

Common side effects include:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal pain

• Hematologic effects: Anemia, thrombocytopenia (low platelet count), leukopenia (low white blood cell count)

• Dermatologic reactions: Skin rash, hair loss

• General symptoms: Fatigue, fever, mouth sores (stomatitis)

Serious but less common side effects may involve:

• Hepatotoxicity: Elevated liver enzymes, jaundice

• Infections: Due to immunosuppression

• Neurological effects: Cerebellar toxicity (affecting balance and coordination)

Patients undergoing treatment with Biobin should be monitored regularly for these potential side effects.