Colozo contains linaclotide, a medicine used to treat certain bowel conditions. It is a synthetic peptide that acts locally in the gut and is prescribed for patients with chronic constipation and irritable bowel syndrome with constipation (IBS-C).

Mechanism of Action

• Linaclotide works by binding to guanylate cyclase-C receptors on the intestinal lining.

• This increases levels of cyclic GMP (cGMP), which stimulates secretion of chloride and water into the intestines.

• The result is softer stools, easier bowel movements, and reduced abdominal pain by calming overactive pain signals in the gut.

  Uses 

  • Irritable bowel syndrome with constipation (IBS-C) in adults

  • Chronic idiopathic constipation (CIC) (long-term constipation without a known cause)

    Adverse Effects

    Common side effects:

    • Diarrhea (can sometimes be severe)

    • Abdominal pain or bloating

    • Gas (flatulence)

    • Headache