Imatib contains imatinib mesylate, a targeted anticancer medicine. It is a tyrosine kinase inhibitor (TKI) used mainly in blood cancers and some solid tumors. It works by blocking abnormal signals that make cancer cells grow uncontrollably.

Mechanism of Action

• Imatinib selectively blocks the BCR-ABL tyrosine kinase, an abnormal protein produced in chronic myeloid leukemia (CML) due to the Philadelphia chromosome.

• It also inhibits other kinases like c-KIT and PDGFR, which are involved in tumor growth.

• By blocking these signals, it prevents cancer cell proliferation and induces apoptosis (programmed cell death).

  Uses 

  Imatib is prescribed for:

  • Chronic myeloid leukemia (CML)

  • Acute lymphoblastic leukemia (ALL) with Philadelphia chromosome positivity

  • Gastrointestinal stromal tumors (GISTs)

  • Certain rare cancers like dermatofibrosarcoma protuberans (DFSP), hypereosinophilic syndrome, and systemic mastocytosis

    Adverse Effects

    Common side effects:

    • Nausea, vomiting, abdominal pain

    • Diarrhea or constipation

    • Muscle cramps, joint pain

    • Swelling (edema), especially around eyes and ankles

    • Skin rash, fatigue, headache