Leuconamo contains Leucovorin Calcium, a reduced form of folic acid (vitamin B9). It is used as a chemoprotective agent to reduce the toxic effects of methotrexate and to enhance the effectiveness of 5-fluorouracil (5-FU) in cancer therapy. It is available in oral tablets or injectable forms and is also used to treat folate deficiency.

Mechanism of Action

• Leucovorin Calcium is converted into tetrahydrofolate, which participates in DNA synthesis and repair.

• With methotrexate: Leucovorin bypasses methotrexate-induced dihydrofolate reductase inhibition, rescuing normal cells from toxicity.

• With 5-FU: It enhances binding of 5-FU to thymidylate synthase, increasing its anticancer efficacy.

  Uses

  • Rescue therapy after high-dose methotrexate.

  • Enhances 5-fluorouracil (5-FU) chemotherapy in colorectal and other cancers.

  • Treatment of folate deficiency or megaloblastic anemia.

  • Reduces toxic effects of certain chemotherapies on normal cells.

    Adverse Effects

    • Nausea, vomiting

    • Diarrhea or abdominal discomfort

    • Rash or mild skin reactions

    • Fever (rare)