Leugard 22.5 mg Depot Injection contains Leuprolide Acetate, a synthetic hormone used in the treatment of various hormone-related conditions. It is a gonadotropin-releasing hormone (GnRH) agonist that, when administered, initially stimulates and then suppresses the production of certain hormones, leading to a decrease in estrogen and testosterone levels. This suppression is beneficial in treating conditions like prostate cancer, endometriosis, uterine fibroids, and central precocious puberty.

Mechanism of Action

Leuprolide Acetate works by overstimulating the pituitary gland, leading to an initial surge in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This surge temporarily increases the production of sex hormones (testosterone in men and estrogen in women). However, continuous administration of Leugard leads to downregulation of GnRH receptors, resulting in a significant decrease in LH and FSH secretion. Consequently, the production of sex hormones is suppressed, which helps in managing hormone-sensitive conditions.

Uses

Leugard 22.5 mg Depot Injection is primarily used for:

• Prostate Cancer: To manage advanced prostate cancer by reducing testosterone levels.

• Endometriosis: To reduce the growth of endometrial tissue and alleviate associated symptoms.

• Uterine Fibroids: To shrink fibroids and reduce symptoms like heavy bleeding and pelvic pain.

• Central Precocious Puberty: To delay early onset puberty in children.

  Adverse Effects

  Common side effects of Leugard 22.5 mg Depot Injection include:

  • Hot flashes

  • Headache

  • Injection site reactions (pain, swelling, redness)

  • Mood changes

  • Fatigue

  • Weight gain