Samisafe is a dietary supplement that contains S-Adenosyl-L-Methionine (SAMe), a naturally occurring compound in the body. It is used to support liver health, joint function, and mood balance. SAMe plays a key role in methylation reactions in the body, which are important for producing neurotransmitters and maintaining healthy liver function.

Mechanism of action:
SAMe acts as a methyl donor in various biochemical reactions. It supports:

• Liver function by aiding detoxification and synthesis of important liver compounds

• Neurotransmitter production (like serotonin, dopamine, and norepinephrine), which can help improve mood

• Joint health by contributing to the formation of cartilage components

Uses:

• Supporting liver health in conditions like fatty liver or mild liver dysfunction

• Reducing symptoms of depression or low mood as an adjunct therapy

• Improving joint pain and mobility in osteoarthritis

Adverse effects:
SAMe is generally well tolerated. Mild side effects may include nausea, diarrhea, constipation, headache, or mild insomnia. Rarely, it can cause anxiety, restlessness, or dizziness. People with bipolar disorder should use caution as it may trigger manic episodes.